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目的探讨黄连素联合阿托伐他汀钙对急性大动脉粥样硬化性脑梗死微栓子信号(MES)的影响。方法 80例急性大动脉粥样硬化性脑梗死患者,随机分为A组和B组,各40例。所有患者均给予常规阿司匹林+阿托伐他汀钙治疗和神经营养药物及康复治疗,B组在常规治疗基础上加用黄连素治疗。随访3个月,比较两组治疗前及治疗3个月后的MES数量、美国国立卫生研究院卒中量表(NIHSS)评分及颈动脉不稳定性斑块数目。结果治疗3个月后,两组的MES数量、NIHSS评分及不稳定性斑块数均显著下降,差异具有统计学意义(P<0.05);且3个月后B组的各项指标均显著低于对照组,差异具有统计学意义(P<0.05)。结论黄连素联合阿托伐他汀钙能控制动脉粥样硬化性斑块的进展,减少MES数量,控制患者病情进展,值得推广应用。
Objective To investigate the effect of berberine combined with atorvastatin calcium on micro-embolus signal (MES) in acute aorta cerebrovascular infarction. Methods Totally 80 patients with acute atherosclerotic cerebral infarction were randomly divided into group A and group B, 40 cases each. All patients were given conventional aspirin + atorvastatin calcium and neurotrophic drugs and rehabilitation therapy, B group on the basis of conventional treatment with berberine. The patients were followed up for 3 months. The number of MES, NIHSS score and carotid instability plaque before treatment and after 3 months of treatment were compared between the two groups. Results Three months after treatment, the number of MES, NIHSS score and the number of unstable plaques in both groups were significantly decreased (P <0.05), and the indexes in group B after 3 months were significantly Lower than the control group, the difference was statistically significant (P <0.05). Conclusions Berberine combined with atorvastatin calcium can control the progression of atherosclerotic plaque, reduce the number of MES, and control the progression of the disease. It is worth popularizing and applying.