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目的:探讨25-OH维生素D〔25-OHVitD〕对妊娠高血压综合征(妊高征)的影响。方法:采用酶联免疫法测定137例妊高征患者(其中轻度妊高征46例、中度妊高征37例、重度妊高征54例)和72例正常妊娠妇女及70例非孕正常妇女的25-OHVitD含量,同时采用放射免疫法测定血栓烷B2(TXB2)、6-酮-前列腺素F1α(6-keto-PGF1α)含量及TXB2/6-keto-PGF1α比值。结果:正常妊娠组和妊高征各组25-OHVitD、TXB2含量及TXB2/6-keto-PGF1α比值明显高于正常非孕组(P<0·01);妊高征各组25-OHVitD含量明显低于正常妊娠组,而TXB2含量及TXB2/6-keto-PGF1α比值明显高于正常妊娠组(P<0·01),并随着妊高征的加重25-OHVitD含量逐渐下降,TXB2含量及TXB2/6-keto-PGF1α比值随之加大。妊高征3组之间比较,采用方差分析F值分别为21·75、9·21和15·45,具有显著性差异(P<0·01)。结论:妊高征的发生与25-OHVitD含量下降、TXB/6-keto-PGF比值升高有关。
Objective: To investigate the effect of 25-OH vitamin D 〔25-OHVitD〕 on pregnancy-induced hypertension (PIH). Methods: 137 PIH patients (including 46 cases of mild PIH, 37 cases of moderate PIH and 54 cases of severe PIH) were detected by enzyme-linked immunosorbent assay (ELISA), 72 normal pregnant women and 70 pregnant women without pregnancy The levels of TXB2, 6-keto-PGF1α and TXB2 / 6-keto-PGF1α in normal women were measured by radioimmunoassay. Results: The 25-OHVitD, TXB2 and TXB2 / 6-keto-PGF1α in normal pregnancy group and PIH group were significantly higher than those in normal non-pregnant group (P <0.01). The 25-OHVitD TXB2 content and TXB2 / 6-keto-PGF1α ratio were significantly higher than those in normal pregnancy group (P <0.01). With the increase of pregnancy-induced hypertension, the content of 25-OHVitD gradually decreased, while TXB2 content And TXB2 / 6-keto-PGF1α ratio increased. PIH among the three groups, using analysis of variance F values were 21 · 75,9 · 21 and 15 · 45, with significant difference (P <0 · 01). Conclusions: The incidence of PIH is related to the decrease of 25-OHVitD and the increase of TXB / 6-keto-PGF ratio.