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甘露醇通过渗透压机制使颅内压降低,但是静滴甘露醇溶液也稀释血液,降低血粘滞度使脑血流增快,随着心脏充盈压和心排血量的增加,还通过自调机制使脑血管收缩(而不完全是由于渗透性脱水),从而缩小脑体积。甘露醇这方面的血流动力学影响,特别是脑血管收缩,目前已可用多普勒超声仪进行观察。为此作者选择10例1～14岁需开颅手术的儿童(除外颅内高压和脑出血者)进行研究。
Mannitol through the mechanism of osmotic pressure to reduce intracranial pressure, but intravenous infusion of mannitol solution also dilute the blood, reducing blood viscosity so that cerebral blood flow faster, with the increase of cardiac filling pressure and cardiac output, but also through the Regulatory mechanisms make cerebral vasoconstriction (not entirely due to osmotic dehydration), thereby reducing brain volume. Mannitol hemodynamic effects in this regard, especially cerebral vasoconstriction, is currently available Doppler ultrasound observations. For this reason, the authors selected 10 children aged 1 to 14 years who underwent craniotomy (excluding intracranial hypertension and intracerebral hemorrhage).