目的　研究双歧杆菌及表面分子脂磷壁酸 (L ipoteichoic acid,L TA)、完整肽聚粮 (Wholepepti- doglycan WPG)、多糖 (Polysaccharide,PS)对猪胃粘膜糖蛋白的粘附作用。方法　采用 EL ISA阻断法测定双歧杆菌表面分子的粘附作用 ,以了解双歧杆菌在定植过程中参与粘附作用的主要表面分子 ,同时也测定了全菌不同菌液浓度的粘附作用。结果　表明 L TA、WPG的粘附作用明显 ,PS粘附作用很弱。粘附随着菌液浓度的增高而增强。结论　在双歧杆菌的定植粘附机理中 ,起主要作用的是该菌菌体表面分子 L TA、 WPG;粘附与菌液浓度相关 Objective To study the adhesion of bifidobacteria and the surface molecules Lpoteichoic acid (LTA), Wholepepti-doglycan WPG and Polysaccharide (PS) to the gastric mucosa glycoproteins. Methods The adhesion of bifidobacteria on the surface of Bifidobacterium was determined by EL-ISA method to find out the major surface molecules involved in the adhesion of Bifidobacterium during colonization. At the same time, . The results showed that LTA, WPG adhesion was obvious, PS adhesion is weak. Adhesion increased with increasing bacterial concentration. Conclusion In the mechanism of colonization and adhesion of Bifidobacterium, LTA and WPG, which play a major role in the bacterial adhesion and bacterial concentration