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为探讨成都地区汉族人群载脂蛋白（ａｐｏ）Ｅ多态性情况及其与血脂、ａｐｏ 之间的关系，作者随机抽取了成都地区健康体检的３６２名汉族成人，采用等电聚焦免疫印迹分析法对其血清ａｐｏＥ表型进行了测定，同时对受检者空腹血ＴＧ、ＴＣ及ａｐｏＡⅠ，Ｂ１００，ＣⅡ，ＣⅢ，Ｅ进行了全面分析。结果显示：成都地区汉族人群ａｐｏＥ表型分布频率为：Ｅ３／３ ７２．９３％ ，Ｅ２／３ １２．９８％ ，Ｅ３／４ １１．３３％ ，Ｅ２／４ １．３８％ ，Ｅ４／４ １．３８％ ，Ｅ２／２未检测到。ＡｐｏＥ等位基因频率为：ε３ ０．８５０８，ε２ ０．０７１８，ε４ ０．０７７４。３６２名汉族成人不同ａｐｏＥ表型的血脂和载脂蛋白水平显示：与ａｐｏＥ３ （Ｅ３／３）或ａｐｏＥ４（Ｅ３／４ ＋ Ｅ４／４ ）组比较，ａｐｏＥ２ （Ｅ２／３ ＋ Ｅ２／２ ）组血清ＴＣ及ａｐｏＢ１００ 明显降低（Ｐ＜ ０．０５），ａｐｏＥ水平明显升高（Ｐ＜０．００１），ＴＧ、ａｐｏＡⅠ、ａｐｏＣⅡ、ａｐｏＣⅢ水平无统计学差异；与ａｐｏＥ３ 组比较，ａｐｏＥ４ 组ＴＧ、ＴＣ、ａｐｏＡⅠ、Ｂ１００、ＣⅡ、ＣⅢ和Ｅ均无统计学差异。
To investigate the relationship between apo E polymorphism and serum lipids and apo in Han nationality in Chengdu area, 362 Han adults were randomly selected for health checkup in Chengdu. The isoelectric focusing immunoblot analysis The serum apoE phenotype was measured, at the same time on the fasting blood TG, TC and apoA Ⅰ, B100, C Ⅱ, C Ⅲ, E conducted a comprehensive analysis. The results showed that the frequencies of apoE phenotype in Han population in Chengdu were: E3 / 72.23%, E2 / 3 12.98%, E3 / 4 11.33%, E2 / 4 1.38%, E4 / 41 .38%, E2 / 2 not detected. The frequencies of ApoE alleles were: ε3 0.8508, ε2 0.0718, ε4 0.0774.362 The serum and apolipoproteins of different apoE phenotypes in Han adults showed that the expression of apoE3 (E3 / 3) or apoE4 (P <0.05), the apoE level was significantly higher (P <0.001), while the levels of TG, apoB100 and apoE2 in apoE2 (E2 / 3 + E2 / There was no significant difference in the levels of apoAⅠ, apoCⅡ, apoCⅢ between apoE3 group and apoE4 group. There was no significant difference in TG, TC, apoAⅠ, B100, CⅡ, CⅢ and E in apoE4 group.