缺血性卒中倾向于凌晨发生,与血压升高有关。这种血压升高可能使易损血管壁受力导致血管的破裂和血栓形成,凌晨α交感神经的血管收缩活性和血小板聚集性增强。作者报告1例在凌晨发病前血压突然升高的男性,60岁,有急性缺血性卒中,轻度高血压史7年,并有非胰岛素依赖型糖尿病,服用Metformin 850mg,2次/d。因1周内2次出现短暂(持续15min)左上肢麻木入院。入院时病人呈窦性心律,未服用降压药,血压22/12kPa,予每天服肠溶阿司匹林325mg,临床检查正常。入院第2天,行24h动态血压监测,病人于6:10醒来下床,6:50至 Ischemic stroke tends to occur early in the morning and is associated with an increase in blood pressure. This increase in blood pressure may cause fragility of the vessel wall leading to rupture of blood vessels and thrombosis, early a sympathetic vasoconstriction activity and platelet aggregation enhanced. The authors report a male patient with a sudden increase in blood pressure before onset of illness in the early morning, 60 years of age with acute ischemic stroke and mild hypertension for 7 years and with non-insulin-dependent diabetes mellitus, taking Metformin 850 mg twice daily. Due to 2 times within 1 week (sustained 15min) left upper limb numbness admitted. Patients were presented with sinus rhythm when the patient was not taking antihypertensive drugs, blood pressure 22 / 12kPa, to enteric-coated aspirin daily 325mg, clinical examination was normal. On the second day of admission, 24-hour ambulatory blood pressure monitoring was performed. The patient got out of bed at 6:10 and went to bed at 6:50