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核心蛋白聚糖是蛋白聚糖(PG)家族中的一员,由一条糖胺聚糖链共价连接于核心蛋白所组成。核心蛋白聚糖的代谢异常或结构改变与许多疾病的病理过程有密切关系。近年研究提示,核心蛋白聚糖对于预防肾脏损伤有一定的作用。本文就核心蛋白聚糖与引起肾间质损害的部分因素之间的作用做一综述。
Decorin is a member of the proteoglycan (PG) family consisting of a glycosaminoglycan chain covalently linked to a core protein. The metabolic abnormalities or structural changes of decorin are closely related to the pathological processes of many diseases. Recent studies suggest that decorin plays a role in preventing kidney damage. This review summarizes the role of decorin and some of the factors that cause damage to the renal interstitium.