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在对同种异体器官移植排斥反应的预防和治疗中,尽管采用了组织配型、移植前输血、抗淋巴细胞球蛋白及单克隆抗体等较为有效的方法,但免疫抑制剂的应用仍未减少。寻求有效、低毒、价廉的排斥反应抑制药物或免疫调节药物依然是移植免疫学的重要课题之一。左旋咪唑(LMS)是一种具有多种作用机制的免疫活性药物,或称为免疫调节剂。它具有双重作用,一是恢复周围效应细胞的功能,二是诱导 T 淋巴细胞
In the prevention and treatment of rejection of allogeneic organ transplantation, the use of immunosuppressive agents has not been reduced despite more effective methods such as tissue matching, transfusion prior to transplantation, anti-lymphocyte globulin and monoclonal antibodies . Seeking an effective, low toxicity, low cost rejection rejection drugs or immunomodulatory drugs remains one of the important topics of transplantation immunology. Levamisole (LMS) is an immunologically active drug with multiple mechanisms of action, or is called an immunomodulator. It has a dual role, one is to restore the function of peripheral effector cells, the second is to induce T lymphocytes