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目的:探讨鼻腔耐受和Wistar大鼠对EAMG耐受的机理。方法:[~3H]TdR掺入和酶联免疫斑点法。结果:免疫后第3、5、7周EAMG大鼠腘窝和腹股沟淋巴结(PILN)中AChR特异的淋巴细包增生反应(LPR)刺激指数比鼻腔耐受大鼠高,第7周比Wistar大鼠高(P<0.05)。免疫后第5、7周EAMG大鼠PILN中AChR反应性γ干扰素分泌细胞数比鼻腔耐受大鼠和Wistar大鼠高(P<0.05)。提示:EAMG发生时淋巴细胞对AChR的免疫应答增强,分泌IFN—γ的Th1样细胞增多。EAMG耐受时,淋巴细胞对AChR的免疫应答降低,分泌IFN—γ的Th1样细胞受抑制。
Objective: To investigate the mechanism of nasal tolerance and Wistar rats tolerance to EAMG. Methods: [~ 3H] TdR incorporation and ELISpot assay. RESULTS: The AChR-specific lymphocyte proliferation (LPR) stimulating index in popliteal and inguinal lymph nodes (PILN) of EAMG rats at 3, 5 and 7 weeks after immunization was higher than that of nasal tolerant rats, Rat high (P <0.05). At 5 and 7 weeks after immunization, the number of AChR-reactive IFN-γ-secreting cells in PILN of EAMG rats was higher than that of nasal tolerant rats and Wistar rats (P <0.05). Tip: EAMG occurs when lymphocytes on the AChR immune response increased, Th1-like cells secreting IFN-γ increased. When EAMG is tolerated, the immune response of lymphocytes to AChR is reduced and Th1-like cells secreting IFN-γ are inhibited.