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用抗氧化剂维生素E预处理后 ,观察三氯乙烯(30 0 0mg/kgB .W .)一次性经口染毒 2 4小时大鼠肝脏的超氧化物歧化酶、谷胱甘肽过氧化物酶等抗氧化酶活力及丙二醛含量的变化。结果表明 ,三氯乙烯染毒组肝脏中丙二醛含量、超氧化物歧化酶活力及血清谷丙转氨酶、谷草转氨酶活力均高于对照组 (P <0 0 1) ,同时 ,肝细胞出现脂肪变与坏死 ;而维生素E干预组的丙二醛含量、超氧化物歧化酶活力及血清谷丙转氨酶、谷草转氨酶活力均分别低于三氯乙烯染毒组 (P <0 0 1) ,肝细胞脂肪变与坏死程度有所改善 ,说明三氯乙烯急性染毒可引起肝脏脂质过氧化反应及肝损害 ,肝脏超氧化物歧化酶活力升高可能是机体受自由基及脂质过氧化反应刺激而诱导产生的一种适应性反应 ,维生素E对三氯乙烯所致的肝损害有一定的保护作用
Pretreatment with antioxidant vitamin E, observed trichlorethylene (30 0mg / kgB .W.) A one-time oral administration of 24 hours rat liver superoxide dismutase, glutathione peroxidase And other antioxidant enzymes activity and MDA content changes. The results showed that malondialdehyde (MDA), superoxide dismutase (SOD) activity, serum alanine aminotransferase (AST) and aspartate aminotransferase (AST) in trichlorethylene exposed group were significantly higher than those in control group (P <0.01) (P <0.01). The levels of malondialdehyde (MDA), superoxide dismutase (SOD) and serum alanine aminotransferase (AST) and aspartate aminotransferase (AST) in the intervention group were lower than those in the trichlorethylene group Steatosis and necrosis improved, indicating that acute exposure to trichlorethylene can cause liver lipid peroxidation and liver damage, liver superoxide dismutase activity may be the body by the free radical and lipid peroxidation stimulation Induction of an adaptive response, vitamin E on trichlorethylene-induced liver damage have a protective effect