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[目的]探讨乳腺癌手术前后血清糖类抗原15-3(CA15-3)和癌胚抗原(CEA)测定的临床意义。[方法]取265例乳腺癌病例外周静脉血,采用电化学发光免疫分析(ECLIA)检测术前及术后CA15-3、CEA水平。[结果]术前已发生转移者23例,CA15-3增高18例,CEA增高10例,阳性率分别为78.3%、43.5%;术后无复发转移组201例,CA15-3增高2例(0.99%)、复发转移组41例,CA15-3增高33例,CEA增高27例,阳性率分别为80.5%和65.9%。[结论]血清CA15-3和CEA的动态检测可作为乳腺癌术后随访的监测指标,CA15-3水平的变化有助于预测肿瘤转移及其治疗效果的判定。
[Objective] To investigate the clinical significance of serum carbohydrate antigen 15-3 (CA15-3) and carcinoembryonic antigen (CEA) before and after breast cancer surgery. [Methods] Peripheral venous blood was collected from 265 cases of breast cancer. The levels of CA15-3 and CEA before and after operation were detected by ECLIA. [Results] Twenty-three cases had preoperative metastasis, CA15-3 increased in 18 cases and CEA increased in 10 cases, the positive rates were 78.3% and 43.5% respectively. There were 201 cases without recurrence and metastasis and 2 cases with CA15-3 increased 0.99%), 41 cases of recurrence and metastasis, 33 cases of CA15-3 increased, 27 cases of CEA increased, the positive rates were 80.5% and 65.9% respectively. [Conclusion] The dynamic detection of serum CA15-3 and CEA can be used as monitoring indicators for postoperative follow-up of breast cancer. The change of CA15-3 level is helpful to predict the metastasis of tumor and its therapeutic effect.