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自Martin(1976)提出存在不同的吗啡受点亚型以来,引起了有关工作者广泛的兴趣。大白鼠输精管(RVD)是常用于研究的离体器官之一,但文献报道有关阿片类化合物对它的作用并不一致。Hughes等(1975)报道,吗啡对RVD电刺激收缩无影响,Schulz等(1979)看到内啡肽及依托啡在很低浓度即可抑制RVD的收缩。Miranda等(1979)及Huidobro-Toro等(1981)则报道吗啡及Etonitazene可使RVD收缩幅度增高。我们观察一些阿片类及阿片肽类化合物对RVD的作用,发现几种阿片肽、依托啡、Etoaitazine、芬泰尼、普鲁丁及3.5桥丙基哌啶等的衍生物对RVD的作用是双相的。在低浓度(4×10~(-2)—8×10~(-7)M)可抑制RVD的收缩,但高浓度(8×10~(-4)—8×10~(-5)M)可使RVD收缩幅度增高,且可引起自发收缩。但未看到吗啡、14羟基吗啡腙等在低浓度时对RVD有抑制作用,而
Since Martin (1976) proposed the presence of different morphine subtypes of morphine, it has aroused widespread interest among the workers concerned. Rat vas deferens (RVD) is one of the most commonly used isolated organs, but the literature reports that opioid effects are not consistent with it. Hughes et al. (1975) reported that morphine had no effect on electrical stimulation of RVD contraction. Schulz et al. (1979) showed that endorphin and etorphine can inhibit RVD contraction at very low concentrations. Miranda et al. (1979) and Huidobro-Toro et al. (1981) reported that morphine and Etonitazene increased RVD shrinkage. We observed the effect of some opioids and opioid peptides on RVD and found that the effect of several opioid peptides, etoposide, Etoaitazine, fentanyl, prudin and derivatives of 3,5-propylpropylpiperidine on RVD is double Phase of. At low concentration (4 × 10 -2 -8 × 10 -7 M), the contraction of RVD was inhibited, but the high concentration (8 × 10 -4 -8 × 10 -5) M) RVD shrinkage can be increased, and can cause spontaneous contraction. But did not see morphine, 14 hydroxymorphine hydrazone and other low concentrations of RVD inhibition, and