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收集初发2型糖尿病患者63例,对其进行空腹血糖(FBG)、空腹胰岛素、血脂、HbA1c、ALD、AngII等生化指标测定,并将其分别分为高血压组21例和非高血压组42例,高糖化血红蛋白(H-HbA1c)组33例和非高糖化血红蛋白(NonH-HbA1c)组30例,老年组35例和非老年组28例,分别进行相关检测指标的分析。结果通过Pearson相关性分析发现ALD、AngII与HbA1c呈显著正相关,并且AngII还与FBG呈显著正相关;ALD、AngII与患者年龄呈显著负相关;高血压组与非高血压组的ALD、AngII未见统计学差异;H-HbA1c组的FBG、HOMA-IR、ALD、AngII均分别高于Non-H-HbA1c组,差异具有统计学意义;老年组的FBG、LDL-C、ALD、AngII均分别低于非老年组,有统计学意义;多元逐步回归后,AngII与HbA1c仍具有显著正相关,ALD与年龄呈显著负向关系。结论2DM患者血循环中的ALD、AngII与2型糖尿病的糖代谢紊乱存在密切关系,并且ALD、AngII还受年龄的影响,干预肾素-血管紧张素-醛固酮系统有助于2DM的治疗。
Sixty-three patients with newly diagnosed type 2 diabetes mellitus were collected and their biochemical indexes such as fasting blood glucose (FBG), fasting insulin, blood lipid, HbA1c, ALD and AngII were determined and divided into 21 cases of hypertension group and non-hypertension group 42 cases, 33 cases of HbA1c group and 30 cases of NonH-HbA1c group, 35 cases of elderly group and 28 cases of non-elderly group, respectively, the relevant testing indicators were analyzed. Results Pearson correlation analysis showed that there was a significant positive correlation between ALD and AngII and HbA1c, and AngII was also positively correlated with FBG; ALD and AngII were significantly negatively correlated with age of patients; ALD and AngII HGA1c group had higher FBG, HOMA-IR, ALD and AngII than Non-H-HbA1c group, the difference was statistically significant; FBG, LDL-C, ALD, AngII Respectively, lower than non-elderly group, with statistical significance; after multiple stepwise regression, AngII and HbA1c still had a significant positive correlation, ALD and age showed a significant negative relationship. Conclusions ALD and AngII in the blood circulation of 2DM patients are closely related to the disorder of glucose metabolism in type 2 diabetes mellitus. ALD and AngII are also affected by age. Intervention with renin - angiotensin - aldosterone system may be helpful for the treatment of 2DM.