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通过214例流行性出血热患者血清与尿液β_2-微球蛋白(β_2-MG)的动态检测,表明发病早期其血β_2-MG。即高达6.85±2.2mg/L,随肾功能损害的出现,血与尿β_2-MG均显著增高(分别为16.9±3.4和12.7±5.1mg/L)。尿β_2-MG≥20mg/L者临床预后欠佳。当肾功能明显改善后,尿β_2-MG显著降低(3.0±1.1mg/L)。随访23例,结果21.7％血β_2-MG持续异常,提示仍有肾功能不全。用于流行性出血热早期诊断,临床监测和判断预后等β_2-MG优于BUN和Cr。
The dynamic detection of β_2-microglobulin (β_2-MG) in serum and urine of 214 patients with epidemic hemorrhagic fever showed that blood β_2-MG in the early stage of the disease. Ie up to 6.85 ± 2.2mg / L. With the appearance of renal dysfunction, blood and urine β_2-MG were significantly increased (16.9 ± 3.4 and 12.7 ± 5.1mg / L, respectively). Urinary β_2-MG ≥ 20mg / L clinical prognosis poor. When renal function improved significantly, urinary β_2-MG was significantly decreased (3.0 ± 1.1mg / L). Follow up of 23 cases, the results of 21.7% blood β_2-MG sustained abnormalities, suggesting that there are still renal insufficiency. It is superior to BUN and Cr for early diagnosis of epidemic hemorrhagic fever, clinical monitoring and prognosis.