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目的考察麻疹-流行性腮腺炎(流腮)-流行性乙型脑炎(乙脑)联合减毒活疫苗(Measles,Mumps and Japanese Encephalitis Combined Attenuated Live Vaccine;M-M-JEV)的稳定性。方法将M-M-JEV,37℃放置7d,检测病毒滴度;2~8℃放置0~25个月,检测外观、水分、病毒滴度、安全试验、异常毒性,0月和18个月时进行全检;(-30±2)℃放置0~30个月,检测外观、水分、病毒滴度、安全试验、异常毒性,0月、18个月、30个月时进行全检。结果所有检测结果,均符合2010年版《中华人民共和国药典》三部麻疹减毒活疫苗、流腮减毒活疫苗和乙脑减毒活疫苗的质量标准。结论 M-M-JEV有较好的稳定性。
Objective To investigate the stability of Measles, Mumps and Japanese Encephalitis Combined Attenuated Live Vaccine (M-M-JEV) with Measles-Mumps (Mastitis) (JE). Methods MM-JEV was stored at 37 ℃ for 7 days, and the virus titer was measured. The virus titer was measured at 2-8 ℃ for 0-25 months. The appearance, water content, virus titer, safety test and abnormal toxicity were measured. (- 30 ± 2) ℃ placed 0 to 30 months, the appearance, water, virus titer, safety tests, abnormal toxicity, 0 months, 18 months, 30 months when the full seizure. Results All the test results were in line with the quality standards of the three live attenuated measles vaccine, live attenuated mumps vaccine and live attenuated JE vaccine in the 2010 edition of the “People’s Republic of China Pharmacopoeia”. Conclusion M-M-JEV has good stability.