Horner—Wittig 反应是合成不饱和化合物的一个重要反应。二十多年来,该反应得到了广泛的应用和发展,尤其是在反应条件的改进上,已有较大的突破。近年来,Mi-Kolajczyk 在两相体系中(有机相/水相),在不用任何相转移催化剂的条件下,进行Horner—Wittig 反应,获得了较理想的结果。但据报导,这种在相转移体系中,不用催化剂就能进行的Horner—Wittig 反应,仅限于与芳香醛反应,而与酮,尤其是与能形成烯醇式结构的酮作用时,反应则完全不能进行。 The Horner-Wittig reaction is an important reaction for the synthesis of unsaturated compounds. More than two decades, the reaction has been widely used and developed, especially in the improvement of reaction conditions, there have been greater breakthroughs. In recent years, Mi-Kolajczyk obtained Horner-Wittig reaction in a two-phase system (organic phase / aqueous phase) without any phase transfer catalyst, and achieved satisfactory results. However, it has been reported that this Horner-Wittig reaction, which can be carried out without a catalyst in a phase-transfer system, is limited to reaction with aromatic aldehydes and reacts with ketones, especially with ketones capable of forming enol structures Can not be done at all.