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中性粒细胞介导的肺损伤在ARDS的发生发展中起着十分重要的作用,抑制白细胞的活化可能成为ARDS的有效治疗措施。本实验研究了己酮可可碱对体外经血小板激活因子(PAF)活化的大鼠血液和腹腔内中性粒细胞功能的影响。结果发现,2.0×10~(-8)mol/L的PAF可使大鼠血中多形核白细胞(PMN)在玻璃珠上的粘附率由
Neutrophil-mediated lung injury plays a very important role in the development of ARDS. Inhibition of leukocyte activation may be an effective treatment for ARDS. This study investigated the effects of pentoxifylline on blood and peritoneal neutrophil function in rats activated by platelet-activating factor (PAF) in vitro. The results showed that the adhesion rate of polymorphonuclear leukocytes (PMN) in rat blood to 2.0 × 10 ~ (-8) mol / L PAF on glass beads was