论文部分内容阅读
目的探讨多中心骨巨细胞瘤(multicentric giant cell tumor of bone,MCGCT)的临床、影像学、病理学特点及手术疗效。方法回顾我科收治的1例MCGCT病例的病史、诊治经过与疗效;同时计算机检索1970年至2014年,Pubmed、Medline、Embase、中国知网、万方数据库、维普数据库等公开发表的文献,并同时配合手工检索已公开发表的骨科学术论文,将其纳入文献一并进行研究讨论。结果本例MCGCT患者随访9个月,其术后疼痛消失,膝关节活动范围为60°,日常生活无明显影响,无复发、转移迹象;检索文献发现目前国内外共有8篇文献报道了70个病例的233个MCGCT的临床、影像学、病理学特点以及治疗方式和预后情况。结论 MCGCT患病率低,以年轻女性患者多见,多位于膝关节周围,较单发骨巨细胞瘤更好发于长骨干骺端,目前病因不祥,肿瘤复发与手术方式有关,应坚持长期随访。
Objective To investigate the clinical features, imaging features and pathological features of multicentric giant cell tumor of bone (MCGCT). Methods A retrospective review of the history, diagnosis and treatment of one case of MCGCT treated in our department and the published literature of Pubmed, Medline, Embase, CNKI, Wanfang database and VIP database from 1970 to 2014 were also performed. At the same time with the manual retrieval of published orthopedic academic papers, incorporated into the literature together to discuss. Results The patients with MCGCT were followed up for 9 months. The postoperative pain disappeared, the range of knee joint activity was 60 °, no significant effect on daily life and no recurrence and metastasis. The retrieved literatures found that there are totally 8 literatures reported in home and abroad for 70 The clinical, radiographic and pathological features of 233 MCGCT cases and their treatment and prognosis were analyzed. Conclusions The prevalence of MCGCT is low. It is more common in young female patients and more in the periphery of knee joint than in single giant cell tumor of bone. It is better than single giant cell tumor in the metaphysis of long bones. Currently, the etiological factor is ominous. The recurrence of the tumor is related to the surgical procedure. Follow-up.