论文部分内容阅读
目的通过Ｔ细胞亚群、ｍＩＬ－２Ｒ等数项免疫检测，以判断自体ＬＡＫ细胞回输治疗慢性活动型肝炎患者的疗效及机理。方法采用ＳＡＣ花环法检测上述指标。结果在应用ＬＡＫ细胞治疗的４０例慢性活动型肝炎（ＣＡＨ）患者中，观察了２４例治疗前后免疫状态的变化。ＣＤ４＋、ＣＤ８＋细胞、ＣＤ４＋／ＣＤ８＋及ｍＩＬ－２Ｒ细胞的百分率治疗前后比较有显著性差异（Ｐ＜０．０１）；治疗前的上述各项结果较正常对照有显著差异（Ｐ＜０．０１）；治疗结束的上述各项结果较正常对照无差异（Ｐ＞０．０５）；而Ｂ１５２细胞治疗前后及与正常对照比较均无差异（Ｐ＞０．０５）。结论自体ＬＡＫ细胞回输治疗结束后的ＣＡＨ患者细胞免疫功能显著提高，这是此疗法发挥效应的机理之一。
Objective To determine the efficacy and mechanism of autologous LAK cell transfusion in the treatment of patients with chronic active hepatitis through several immune tests such as T cell subsets and mIL-2R. Methods SAC rosette method to detect the above indicators. Results In 40 patients with chronic active hepatitis (CAH) treated with LAK cells, the changes of immune status in 24 patients before and after treatment were observed. The percentage of CD4 +, CD8 + cells, CD4 + / CD8 + and mIL-2R cells before and after treatment were significantly different (P <0.01). The above results before treatment were significantly different from the normal control (P <0.01) (P> 0.05). However, there was no significant difference between the two groups (P> 0.05) before and after B152 treatment and compared with the normal control. Conclusions The cellular immune function of CAH patients after autologous LAK cell transfusion is significantly improved, which is one of the mechanisms by which this therapy exerts its effect.