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采用重组基因工程干扰素α－2b分别以两种剂量治疗慢性乙型肝炎（CHB）254例，其中甲组130例，每次100万单位，乙组124例，每次300万单位，隔日一次肌注，连用3个月，观察两种剂量的干扰素对CHB疗效的影响。结果血清ALT及胆红素复常率乙组高于甲组，统计学处理两组差异显著（P＜0.05），HBV－M结果示HBeAg、抗－HBcIgM、HBV－DNA阴转率及抗－HBe阳转率乙组亦优于甲组（P＜0．05），说明适当增加干扰素剂量，可提高对CHB的疗效．但大利量干扰素亦可增加不良反应应予以注意。
A total of 254 patients with chronic hepatitis B (CHB) were treated with recombinant human interferon alpha-2b in two doses, 130 cases in group A were treated with 1 million units each, and 124 cases in group B were treated with 300 million units at one time every other day Intramuscular injection, once every 3 months, observed the effect of two doses of interferon on the efficacy of CHB. Results The levels of serum ALT and bilirubin in group B were higher than those in group A (P <0.05). The results of HBV-M showed HBeAg, anti-HBcIgM, HBV-DNA negative rate and anti- The positive rate of HBe in group B was also better than that in group A (P <0.05), indicating that the appropriate dose of interferon could improve the efficacy of CHB. But the amount of interferon can also increase the adverse reactions should be noted.