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目的观察大鼠正畸牙移动过程中血小板衍生生长因子-AA(PDGF-AA)在牙周组织内的表达变化,探讨PDGF-AA在正畸牙周组织改建中的作用。方法取健康成年雄性Wistar大鼠随机分为对照组、牙齿移动1、7、14、21天组,每组8只。建立大鼠正畸牙移动动物模型,用免疫组织化学方法检测牙周组织中PDGF-AA的表达。结果大鼠牙周组织中PDGF-AA表达阳性,主要表达在成纤维细胞、成骨细胞、血管内皮细胞胞浆内,实验组强于对照组,在同一实验组中,张力侧的表达均较压力侧强,加力7天为表达的高峰期。结论 PDGF-AA在正畸牙移动的牙周组织改建中起重要作用,主要参与了成骨活动。
Objective To observe the expression of PDGF-AA (PDGF-AA) in periodontal tissues during orthodontic tooth movement and to explore the role of PDGF-AA in orthodontic periodontal tissue remodeling. Methods Healthy adult male Wistar rats were randomly divided into control group, teeth moving 1,7,14,21 days group, each group of eight. The rat model of orthodontic tooth movement was established, and the expression of PDGF-AA in periodontal tissues was detected by immunohistochemistry. Results The expression of PDGF-AA in periodontal tissues of rats was positive, which was mainly expressed in the cytoplasm of fibroblasts, osteoblasts and vascular endothelial cells. The experimental group was stronger than the control group. In the same experimental group, the expression of PDGF- Strong pressure side, afterburner 7 days for the expression of the peak. Conclusion PDGF-AA plays an important role in the reconstruction of periodontal tissues during orthodontic tooth movement, and is mainly involved in osteogenic activity.