【摘 要】
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BACKGROUND AND OBJECTIVECarotid endarterectomy (CEA) is performed to prevent stroke in patients with high-grade carotid artery stenosis. Carotid artery stenting (CAS) is being investigated as an alter
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BACKGROUND AND OBJECTIVECarotid endarterectomy (CEA) is performed to prevent stroke in patients with high-grade carotid artery stenosis. Carotid artery stenting (CAS) is being investigated as an alternative intervention. This study evaluated the cognitive performance of patients with severe, asymptomatic carotid artery stenosis undergoing CAS.
METHODSSubjects were adults, 55 to 80 years of age, undergoing CAS for asymptomatic, unilateral, internal carotid artery stenosis of more than 70%. All subjects underwent cognitive assessment, as well as brain imaging, including pulsed arterial spin labeling (pASL), amplitude of low frequency fluctuation(ALFF) and resting state functional MRI (R-fMRI).
RESULTSBetween baseline and 3 months post-surgery, significant improvements were noted in the Mini-Mental State Exam, Verbal Memory Test, and Delayed Recall. An increase in cerebral blood flow, mainly in the left frontal gyrus, anterior cingulate, left occipital gyrus and left cerebellum was noted after surgery. No significant differences were found between changes in imaging and cognitive assessment.
CONCLUSIONThis study of patients with asymptomatic carotid stenosis found that carotid artery stenting can improve cognition, as well as cerebral perfusion.
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