IL-10具有多种生物学功能,其中一个主要功能是能抑制Th1 CD4~+,CD8~+和NK细胞合成IFN-γ。有实验观察到,在寄生虫感染时,IL-10的产生伴有IFN-γ产生的降低或加重感染。本文作者对IL-10抑制IFN-γ依赖性的抗寄生虫感染的免疫机制进行了研究。作者选择细胞内寄生的弓形虫和细胞外寄生的曼氏血吸虫作为研究的靶子,以腹腔渗出的巨噬细胞作为效应细胞,于体外试 IL-10 has multiple biological functions. One of the major functions of IL-10 is its ability to inhibit the synthesis of IFN-γ by Th1 CD4 ~ +, CD8 ~ + and NK cells. It has been experimentally observed that the production of IL-10 is accompanied by a decrease or aggravation of infection of IFN-γ production during parasite infection. The authors investigated the immune mechanism of IL-10 in inhibiting IFN-y-dependent anti-parasitic infections. The authors chose intracellular parasitic Toxoplasma gondii and extracellular parasitic Schistosoma mansoni as a research target to peritoneal exudate macrophages as effector cells in vitro test