目的　了解班布特罗对慢性阻塞性肺病 (COPD)患者夜间血氧饱和度的影响。方法　 11例COPD相对缓解期的男性患者 ,于 2 3时开始连续检测血氧饱和度 (SaO2 )直至次日 6时 ,同时记录夜间事件。然后 ,病人于当日 18时开始服用班布特罗 10mg ,每日 1次 ,连服 2天 ,于用药第 2日的 2 3时开始连续检测血氧饱和度 (SaO2 )直至次日 6时。同时记录夜间事件。结果　用药前后患者SaO2 均值比较 :用药前均值 92 1± 0 0 5 ,用药后均值 92 8± 0 0 5。用药后SaO2 出现了具有统计学意义的增加 (P值 <0 0 0 1)。用药后 6个小时观测 ,每小时的SaO2 均值均高于用药前各该时点的SaO2 均值 ;而且 ,在第 1、3、4、5时点 ,用药前后的差异具有统计学意义。结论　班布特罗具有改善COPD患者夜间SaO2 恶化加重的作用 ,因此 ,在COPD中使用班布特罗是安全、有效的 Objective To understand the effect of bambuterol on nocturnal oxygen saturation in patients with chronic obstructive pulmonary disease (COPD). Methods A total of 11 male patients with COPD were included in the study. Continuous blood oxygen saturation (SaO2) was measured at 2-3 days and nighttime events were recorded at 6:00 the following day. The patient then started taking bambuterol 10 mg once daily at 18:00 of the same day for 2 consecutive days. Continuous blood oxygen saturation (SaO2) was measured at 23:00 on the 2nd day of the medication until 6:00 of the next day. Record nighttime events at the same time. Results Before and after treatment, the mean SaO2 of patients was 92 1 ± 0 0 5 before treatment and 92 8 ± 0 0 5 after treatment. There was a statistically significant increase in SaO2 after treatment (P <0 0 0 1). Six hours after treatment, the mean SaO2 per hour was higher than the mean SaO2 at each time point before treatment. Moreover, the difference between before and after treatment was statistically significant at the 1st, 3rd, 4th and 5th points. Conclusions Bambuterol has the potential to improve the worsening of nightly SaO2 in COPD patients and therefore, the use of bambuterol in COPD is safe and effective