论文部分内容阅读
目的:评估贝宁最大的结核病中心科托努地区目前抗结核药物的耐药形势。方法:共计分析从肺结核患者分离出的470株结核分枝杆菌复合群:其中244株来自新病人, 226株来自复治病人。使用比例法对分离菌株进行一线药物的敏感性试验。结果:原发耐多药情况与患者的来源有关:若分析所有的患者,则新病人中耐多药相对较高(1.6%);若仅考虑贝宁常住人口,该比例则较低(0.5%),并与1994年国家的耐药监测结果比较。复治患者的耐多药率(11.1%),也与贝宁1994年的耐药监测结果持平。没有发现合并感染人类免疫缺陷病毒与抗结核药物的耐药性相关。结论:本研究表明在流行病学调查中正确的区分患者的重要性,研究人口不同,结果就可能不相同。
Purpose: To assess the prevalence of anti-TB drug resistance in the Cotonou region, the largest tuberculosis center in Benin. METHODS: A total of 470 M. tuberculosis complex isolates from patients with tuberculosis were analyzed in total: 244 of them were from new patients and 226 from retreatment patients. The sensitivity of the isolated strains to first-line drugs was tested using the proportional method. Results: The prevalence of primary MDR was related to the source of the patient: MDR was relatively high (1.6%) in the new patient if all patients were analyzed; the proportion was lower when considering only the resident population in Benin (0.5 %) And compared with the results of drug resistance surveillance in the country in 1994. MDR rates in retreatment patients (11.1%) were also in line with the results of the drug resistance monitoring in Benin in 1994. No co-infection with human immunodeficiency virus was found associated with resistance to anti-TB drugs. CONCLUSIONS: This study shows the importance of correctly distinguishing patients from epidemiological surveys. The study population may vary and the results may differ.