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肾移植术后如何了解移植受者术后的免疫状态 ,合理应用免疫抑制药物 ,在免疫不足和免疫过度之间取得平衡 ,仍是移植医生面临的难题。通过血中免疫抑制药物浓度的测定 ,结合外周血中的T细胞亚型、细胞因子、细胞粘附分子、含供者基因的微嵌合体、术后PRA水平的测定以及移植肾穿刺标本和细针抽吸细胞的免疫学检查、供受者特异性淋巴细胞体外混合培养反应情况的检测 ,才能较为准确地了解和评价移植受者术后的免疫状态。
After transplantation, how to understand the postoperative immune status of transplant recipients and to use immunosuppressive drugs rationally to balance imbalance between immunosuppression and immunosuppression remains a challenge faced by transplant doctors. Through the determination of the concentration of immunosuppressive drugs in blood and the combination of T cell subtypes, cytokines, cell adhesion molecules, microdimers with donor genes, postoperative levels of PRA and transplanted renal biopsy specimens Needle aspiration cells immunological examination for recipient-specific lymphocytes in vitro mixed culture reaction detection in order to more accurately understand and evaluate the immune status of transplant recipients.