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目的观察猪肺磷脂注射液不同给药方式治疗新生儿呼吸窘迫综合征(NRDS)的疗效。方法收集新生儿科2014年3月-2017年3月收治的NRDS患儿208例,根据治疗方法不同分为观察组144例和对照组64例,观察组给予猪肺磷脂注射液快速给药法气管注入,对照组给予微量缓慢给药法气管内注入,2组给药后均予以经鼻持续气道正压通气(NCPAP)治疗,比较2组治疗前、治疗后动脉血pH、氧分压(PaO_2)、二氧化碳分压(PaCO_2)、氧疗时间、NCPAP时间、住院时间、需要再次用药率和并发症发生率。结果 2组患儿治疗前动脉血pH、PaO_2、PaCO_2比较差异无统计学意义(P>0.05);治疗后2组pH、PaO_2、PaCO_2均显著改善,且观察组优于对照组,差异均有统计学意义(P<0.05)。观察组NCPAP时间、氧疗时间、住院时间均短于对照组,差异均有统计学意义(P<0.05)。观察组需要再次用药发生率、支气管肺发育不良(BPD)、机械通气发生率及病死率均低于对照组,差异有统计学意义(P<0.05);2组颅内出血发生率差异无统计学意义(P>0.05)。结论猪肺磷脂注射液快速给药法气管内注入联合NCPAP治疗NRDS疗效显著,可减少再次用药和用氧时间,减少BPD发生,值得临床推广。
Objective To observe the therapeutic effect of different administration methods of pulmonary phlebitis injection on neonatal respiratory distress syndrome (NRDS). Methods A total of 208 children with NRDS who were admitted to the Department of Neonatology between March 2014 and March 2017 were divided into observation group (n = 144) and control group (n = 64) according to different treatment methods. The observation group was administered with pulmonary phlebitis injection The rats in the control group were treated with tracheal intratracheal instillation by slow tracheal injection. Nasal continuous positive airway pressure ventilation (NCPAP) was used in both groups before and after treatment. The arterial blood pH, partial pressure of oxygen ( PaO2, PaCO2, Oxygen therapy time, NCPAP time, hospital stay, need for re-dosing and complication rates. Results There was no significant difference in arterial blood pH, PaO_2 and PaCO_2 between the two groups before treatment (P> 0.05). The pH, PaO_2 and PaCO_2 of two groups were significantly improved after treatment, and the observation group was better than the control group Statistical significance (P <0.05). The observation group NCPAP time, oxygen therapy time, hospitalization were shorter than the control group, the difference was statistically significant (P <0.05). The incidence of recurrent medication, bronchopulmonary dysplasia (BPD), mechanical ventilation and mortality in the observation group were lower than those in the control group (P <0.05). There was no significant difference in the incidence of intracranial hemorrhage between the two groups Significance (P> 0.05). Conclusions The rapid pulmonary administration of phosphatidylcholine injection of NCPAP combined with intratracheal intratracheal intratracheal instillation of NRDS has significant curative effect, which can reduce the re-use of medication and time of oxygenation and reduce the incidence of BPD, which deserves clinical promotion.