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本文根据Blorm－Richarcisonde分级标准对46例浸润性导管癌进行分析，同时采用S－P法对其进行C－erbB2癌基因和ER、PR免疫组织化学标记。结果：组织学Ⅰ级Ⅱ例，C－erbB2癌基因和ER、PR的阳性率分别为18．12％、63％和、54％；组织学Ⅱ级25例，C－erbB2癌基因和ER、PR的阳性率分别为28％、48％和32％组织学Ⅲ级10例，C－erbB2癌基因和ER、PR的阳性率分别为40％、20％和10％。从而表明组织学分级越差，C－erbB2癌基因的过度表达越强，ER、PR阳性率越低，淋巴结转移的机率越高．组织学分级与C－erbB2癌基因的过度表达呈正相关，与ER、PR水平呈负相关，与淋巴结转移率呈正相关．C－erbB2癌基因过度表达预后差，复发及转移率高，RP、PR阳性率高提示预后好，复发、转移率低。
According to the Blorm-Richarcisonde classification criteria, 46 cases of invasive ductal carcinoma were analyzed, and C-erbB2 oncogenes and ER and PR immunohistochemical markers were performed by S-P method. RESULTS: The histological grade II cases, C-erbB2 oncogene and ER, PR positive rates were 18.12%, 63% and 54%; histological grade II 25 cases, C-erbB2 oncogene and ER, The positive rates of PR were 28%, 48%, and 32% of histological grade III. The positive rates of C-erbB2 oncogene and ER and PR were 40%, 20%, and 10%, respectively. Thus, the worse the histological grade, the stronger the overexpression of C-erbB2 oncogene, the lower the positive rate of ER and PR, and the higher the chance of lymph node metastasis. Histological grade was positively correlated with overexpression of C-erbB2 oncogene, negatively correlated with ER, PR, and positively correlated with lymph node metastasis. The prognosis of C-erbB2 oncogene overexpression is poor, and the recurrence and metastasis rate are high. The high positive rates of RP and PR indicate a good prognosis, and the recurrence and metastasis rate are low.