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目的研究血管内皮细胞生长因子-C(vascular endothelail growth factor-C,VEGF-C)在皮肤恶性黑素瘤(cutaneous malignant melanoma,CMM)中的表达。方法应用免疫组化S-P法检测血管内皮细胞生长因子-C在交界痣30例、皮肤恶性黑素瘤30例及15例正常皮肤组织中的表达。结果皮肤恶性黑素瘤中血管内皮细胞生长因子-C的阳性表达率明显高于交界痣和正常对照组(P<0.05),交界痣与正常对照组相比,无显著性差异(P>0.05)。结论血管内皮细胞生长因子-C的高表达可能与皮肤恶性黑素瘤的发生发展有关,有望作为临床治疗黑素瘤的突破点。
Objective To study the expression of vascular endothelin growth factor-C (VEGF-C) in cutaneous malignant melanoma (CMM). Methods Immunohistochemical S-P method was used to detect the expression of vascular endothelial growth factor-C in borderline nevus in 30 cases, 30 cases of malignant melanoma and 15 cases of normal skin tissue. Results The positive rate of VEGF expression in malignant melanoma was significantly higher than that in junctional nevus and normal control group (P <0.05). There was no significant difference between border nevus and normal control group (P> 0.05 ). Conclusion The high expression of vascular endothelial growth factor-C may be related to the occurrence and development of malignant melanoma in skin, which is expected to serve as a breakthrough point for clinical treatment of melanoma.