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目的 探讨帕金森病 (PD)患者的苍白球内侧部 (GPi) ,丘脑腹外侧中间核 (Vim)及丘脑底核 (STN)的电生理特性。方法 用立体定向毁损术治疗 54例PD手术中 ,应用美国FHC公司生产的微电极记录系统 ,记录GPi、Vim和STN不同部位的电活动。结果 PD病人的丘脑内和基底节不同结构部位的电活动频率、幅度、放电方式和背景噪声均有显著差异 ;Vim中可记录到与震颤同步的高频放电 ,GPi、STN可记录到一致稳定的放电活动。结论 利用GPi、Vim和STN不同部位的电活动特性 ,可以为立体定向治疗PD手术中的精确定位 ,提高疗效 ,降低并发症提供参考依据
Objective To investigate the electrophysiological characteristics of the medial pallidus (GPi), the midbrain of the thalamus (Vim) and the subthalamic nucleus (STN) in patients with Parkinson’s disease (PD). Methods Stereotaxic surgery was used to treat 54 PD patients. The microelectrode recording system produced by American FHC Company was used to record the electrical activities of different parts of GPi, Vim and STN. Results There was a significant difference in electrical activity frequency, amplitude, discharge pattern and background noise among PD patients’ thalamus and basal ganglia. Vim was synchronized with tremor and GPi and STN could be recorded consistently Discharge activity. Conclusion The electrical activity characteristics of different sites of GPi, Vim and STN can provide a reference for stereotactic PD surgery to improve the accuracy and reduce the complications