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目的研究非小细胞肺癌(NSCLC)组织中胸苷酸合成酶(TS)及表皮生长因子受体(EGFR)蛋白的表达及其临床意义。方法免疫组化方法检测431例NSCLC组织中TS及EGFR蛋白表达,评估其与临床病理参数的关系。结果 TS蛋白在NSCLC组织中阳性表达率为35.1%(134/382);其表达水平与肿瘤分化程度及淋巴结转移有关(P<0.05)。EGFR蛋白在NSCLC组织中阳性表达率为74.1%(312/421);其表达水平与病理类型、分化程度及淋巴结转移情况有关(P<0.05)。结论 TS及EGFR蛋白表达与部分临床病理参数相关,对NSCLC诊断及预后的判断可能具有重要价值。
Objective To investigate the expression and clinical significance of thymidylate synthase (TS) and epidermal growth factor receptor (EGFR) proteins in non-small cell lung cancer (NSCLC). Methods Immunohistochemical method was used to detect the expression of TS and EGFR protein in 431 cases of NSCLC and evaluate the relationship between the expression of TS and EGFR and clinicopathological parameters. Results The positive expression rate of TS protein in NSCLC tissues was 35.1% (134/382). The expression level of TS protein was related to tumor differentiation and lymph node metastasis (P<0.05). The positive expression rate of EGFR protein in NSCLC tissues was 74.1% (312/421); its expression level was related to histological type, differentiation degree and lymph node metastasis (P<0.05). Conclusion The expression of TS and EGFR protein is associated with some clinicopathological parameters, which may have important value in the diagnosis and prognosis of NSCLC.