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由于红细胞生成的数量不足所致的贫血为结缔组织疾病的常见并发症。虽然在此类疾病中抗成熟红细胞抗体常见,但有关红系干细胞抑制物的存在却罕有报道。本文作者利用关于红系干细胞成长的无性繁殖系实验系统,以研究结缔组织疾病的贫血发生原因。从8名正常同种异体供者及2例结缔组织疾病病人获取的骨髓细胞在有或缺正常供者及10例结缔组织疾病病人(3例类风湿性关节炎、7例系统性红斑狼疮)的血清的情况下分别进行培养。正常的同种异体骨髓细胞加入6例具有贫血的结缔组织疾病病人(血细胞比容16～25%)的血清可减少红系细胞群的形成达60～95%;相反,如加入4例无贫血的结缔组织疾病病人(血细胞比容37～41%)的血
Anemia due to an insufficient number of erythropoiesis is a common complication of connective tissue disease. Although anti-mature erythrocytic antibodies are common in such diseases, the existence of erythroid stem cell inhibitors is rarely reported. The authors used an experimental system of clonal propagation of erythroid stem cells to study the causes of anemia in connective tissue diseases. Bone marrow cells obtained from 8 normal allogeneic donors and 2 patients with connective tissue disease were present in patients with and without normal donor and 10 patients with connective tissue disease (3 with rheumatoid arthritis and 7 with systemic lupus erythematosus) In the case of serum. Normal allogeneic bone marrow cells added to 6 patients with anemia of connective tissue disease (hematocrit 16-25%) serum can reduce the formation of erythroid cells up to 60 to 95%; on the contrary, as adding 4 cases of anemia Of connective tissue disease patients (hematocrit 37 to 41%) of the blood