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目的构建一种新型的能应用于射频消融(radio frequency ablation,RFA),并且与人肝组织特征相似的仿真模型。方法用新鲜动物离体肝组织匀浆、琼脂糖凝胶、脱气水制成仿正常肝组织的固体模型,测定其物理特性,并对模型进行RFA操作,测量单次RFA的消融体积,评估模型行RFA的生物特性。结果肝组织凝胶模型密度为(1 055.75±9.29)kg/m3,比热容为(3 446±137)J/(kg·℃),导电率为(0.123±0.004)s/m(470 kHz),CT值为(25.68±5.85)HU,与人体肝脏的物理特征类似;单次RFA后剖开模型可见清晰消融灶,肉眼或CT扫描下均可测量毁损灶大小。结论新型肝组织凝胶模型具有较好的仿人肝组织的特点。
Objective To construct a novel simulation model that can be applied to radio frequency ablation (RFA) and is similar to human liver tissue. Methods A solid model of normal liver tissue was made from fresh liver homogenate, agarose gel and degassed water. The physical characteristics of the model were measured, and the model was subjected to RFA operation. The volume of a single RFA ablation was measured. The biological characteristics of the model line RFA. Results The hepatic tissue gel model density was (1 055.75±9.29) kg/m 3 , the specific heat capacity was (3 446±137) J/(kg·°C), and the conductivity was (0.123±0.004)s/m (470 kHz). The CT value was (25.68±5.85) HU, which was similar to the physical characteristics of the human liver. A single RFA post-sectioning model showed clear lesions, and the lesion size could be measured under the naked eye or under CT scan. Conclusion The new liver tissue gel model has better human liver tissue characteristics.