骨髓移植在急性白血病和再障的治疗中起着重要作用,但只能用于主要组织相容性抗原相合者。在找不到合适供髓者的情况下,胎肝可能是造血干细胞的另一来源。作者报告2例复发期急性白血病患者在大剂量环磷酰胺(CY)和全身照射(TBI)后输注新鲜胎肝的结果。例1、11岁男孩。急性粒细胞白血病,第一次复发后,于强烈联合化疗后自体骨髓移植而缓解。在第二次复发又强烈联合化疗后输入冷冻贮存的16周胎龄的胎肝细胞(2×10~8有核细胞K/g),受者红细胞同工酶型为AK1-1,胎肝细胞为AK2-1,2月后红细胞同工酶型100％为AK2-1。第三次复发于CY和TBI后输注了 Bone marrow transplantation plays an important role in the treatment of acute leukemia and aplastic anemia, but only for the major histocompatibility complex. In the absence of a suitable donor, fetal liver may be another source of hematopoietic stem cells. The authors report the results of two patients with recurrent acute leukemia infused with fresh fetal liver after high-dose cyclophosphamide (CY) and total body irradiation (TBI). Example 1, 11-year-old boy. Acute myeloid leukemia, after the first relapse, is relieved by autologous bone marrow transplantation after a strong combination of chemotherapy. Frozen fetal liver cells (2 × 10-8 nucleated cells K / g) were stored frozen for 16 weeks in the second recurrent and intensive combination chemotherapy. The recipients’ erythrocyte isoforms were AK1-1, fetal liver Cells were AK2-1, 2 months after redox cells were 100% AK2-1. The third relapse occurred after the CY and TBI transfusions