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目的研究体外受精促超排卵过程中激素水平的变化,探讨激素水平与临床妊娠的相关性。方法476个IVF-ET及ICSI周期,应用单因素和多因素Logistic回归分析,研究患者的基础FSH、LH、E2、P,启动日LH、E2、P,HCG注射日LH、E2、P与临床妊娠的相关性。结果:单因素Logistic回归分析:基础激素水平、启动日激素水平和HCG日E2与临床妊娠未见明显相关性,HCG日LH、P与临床妊娠明显相关。多因素Logistic回归分析:HCG日LH、P与临床妊娠明显相关(P分别=0.020、0.020,Exp(B)分别为1.147、0.766),回归方程为Logit(P)=-0.502+0.138*(HCG日LH)-0.266*(HCG日P)。结论HCG注射日LH、P与临床妊娠具有明显相关性,LH水平过低或P水平过高对临床妊娠不利。建议当HCG日P水平过高时,可以考虑取消新鲜胚胎移植,择期行冷冻胚胎移植。
Objective To study the changes of hormones during IVF and ovarian hyperstimulation, and to explore the correlation between hormones and clinical pregnancy. Methods 476 IVF-ET and ICSI cycles were studied by single factor and multivariate logistic regression analysis. The basis of FSH, LH, E2, P, LH, E2, P, LH, E2, Pregnancy relatedness. Results: Univariate logistic regression analysis showed that there was no significant correlation between basal hormone level, priming hormone level and E2 on HCG day and clinical pregnancy. LH and P on HCG day were significantly correlated with clinical pregnancy. Multivariate logistic regression analysis showed that LH and P were significantly correlated with clinical pregnancy (P = 0.020,0.020, Exp (B) = 1.147,0.766, respectively) on HCG day and the regression equation was Logit (P) = -0.502 + 0.138 * Day LH) -0.266 * (HCG Day P). Conclusions LH and P on HCG injection date have obvious correlation with clinical pregnancy. Low LH or high P level is unfavorable to clinical pregnancy. Proposed HCG when the P level is too high, you can consider abolishing fresh embryo transfer, elective frozen embryo transfer line.