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目的探讨钙离子通道阻滞剂－异搏定滴眼剂对眼压及视网膜中央动脉血流的影响。方法25例健康志愿者右眼点1．25g·L(-1)异搏定滴眼剂，应用压平式眼压计及彩色多普勒超声检查仪，观察其对眼压及视网膜中央动脉血流的影响。结果局部应用1．25g·L(-1)异搏定滴眼，对心率和血压无影响，用药2h后眼压明显下降，视网膜中央动脉收缩期、舒张末期血流速度明显增加，而血管阻抗指数则明显下降。结论局部应用1．25g·L(-1)异搏定滴眼剂可降低眼内压并能改善视网膜视神经血液循环。
Objective To investigate the effect of calcium channel blocker-verapamil on intraocular pressure and central retinal artery blood flow. Methods Twenty-five healthy volunteers were given 1.25g · L (-1) verapamil eyedrops at the right eye point. The effects of intraocular pressure (IOP) and central retinal artery The impact of blood flow. Results Topical application of verapamil 1.25g · L (-1) drops, no effect on heart rate and blood pressure, after 2h medication intraocular pressure decreased significantly central retinal artery systolic and diastolic blood flow velocity increased significantly, and vascular resistance The index dropped significantly. Conclusion Topical application of verapamil 1.25g · L (-1) may reduce intraocular pressure and improve retinal blood flow in the optic nerve.