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目的回顾性分析６２例眼外期视网膜母细胞瘤，研究其预后。材料与方法北京医院放射治疗科自１９８０年６月至１９９１年６月共收治了８７例１１３只眼视网膜母细胞瘤（ＲＢ）患者，平均年龄３岁。６２例属眼外期，其中５８例行单侧或双侧眼球摘除术，１９例术后断端经病理证实有残留病变，５８例行术后体外放射治疗。４例单纯体外放射治疗。肿瘤量ＤＴ以５０～６０Ｇｙ／５～６周为主。结果６２例眼外期视网膜母细胞瘤患者的１，３，５年生存率分别为４８％，２９％，２３％，与同期眼内期２２例患者相比，差异有显著意义。而术后有残留病变的１９例患者，则分别为２６％，１６％，１０％，与术后无残留的比较，差异无显著意义，但非残留患者死亡风险小。结论早期发现早期治疗是治愈视网膜母细胞瘤的关键，但晚期患者如通过手术切除眼球及内容物，合并术后体外放射治疗，仍有部分患者可获得治愈。术后断端是否有肿瘤残留患者的预后差异统计学上无明显意义。但残留病变的患者死亡危险性较非残留者大
Objective To retrospectively analyze 62 cases of extraocular retinoblastoma and study its prognosis. Materials and Methods Radiotherapy department of Beijing Hospital treated 87 eyes of 113 patients with retinoblastoma (RB) from June 1980 to June 1991, with an average age of 3 years. Sixty-two cases were in extraocular stage, of which 58 cases underwent unilateral or bilateral enucleation and 19 cases had residual lesions confirmed by pathology. Fifty-eight patients underwent external beam radiotherapy. 4 cases of extracorporeal radiation therapy. Tumor volume DT to 50 ~ 60Gy / 5 ~ 6 weeks based. Results The 1, 3, 5-year survival rates of 62 cases of extraocular retinoblastoma were 48%, 29%, 23% respectively, which were significantly different from those of 22 cases of intraocular phase. The postoperative residual disease in 19 patients, respectively, 26%, 16%, 10%, compared with no postoperative residual, the difference was not significant, but the risk of death in non-residual patients is small. Conclusion Early detection of early treatment of retinoblastoma is the key to cure, but in patients with advanced surgery, such as surgical removal of the eye and the contents of the combined postoperative external beam radiotherapy, there are still some patients can be cured. There was no statistically significant difference in the prognosis of the patients with residual tumor after surgery. However, patients with residual disease are at greater risk of dying than non-survivors