目的　观察机体的特异性免疫细胞克隆 ,在受到非对应性抗原刺激后的反应情况。方法　首先用定量的卵白、牛乳和牡蛎提取液 (依次简称为EW、MI、OE抗原 ) ,分别对家兔做基础免疫 ,再分别用EW、MI、OE 3种抗原对家兔做交叉免疫。采用酶联免疫法 ,定量检测各组交叉免疫前、后的基础抗体的变化。结果　采用与基础免疫不同的抗原做交叉免疫的各组家兔 ,其基础抗体均有 10 %～ 2 5 %的提高 ,较对照组有显著差异 (P <0 .0 5 )。结论　免疫特异性反应细胞克隆可被非对应抗原激活 Objective To observe the response of specific immune cell clones after being stimulated by non-corresponding antigens. Methods The rabbits were immunized with quantitative protein, milk and oyster extracts (EW, MI and OE antigen, respectively), and then the rabbits were immunized with EW, MI and OE antigens respectively. Enzyme-linked immunosorbent assay was used to quantitatively detect the change of basal antibody before and after cross-immunization. Results The rabbits in each group were crossed with different antigens of basal immunity. The basal antibodies of them increased by 10% ~ 25%, which was significantly different from that of the control group (P <0.05). Conclusion Immunospecific cell clones can be activated by non-corresponding antigens