维甲酸类化合物通过激活其核受体蛋白来调控核基因的表达， 在细胞的生长、分化和细胞生理凋亡方面起重要作用。不同类型维甲酸核受体蛋白可以调控不同基因的表达，产生不同的药理性质，故定向设计只作用于一种或几种受体的维甲酸类化合物分子，对于研究维甲酸类化合物作用的分子机制、核基因调控的方式和途径，以及合成新作用机制高活性、低毒副作用的维甲酸类化合物有重要意义 Retinoids regulate the expression of nuclear genes by activating their nuclear receptor proteins and play an important role in cell growth, differentiation and cell physiology. Different types of retinoic acid nuclear receptor protein can regulate the expression of different genes, resulting in different pharmacological properties, so the directional design of only one or several receptors retinoid molecules, for the study of retinoid molecules Mechanism, nuclear gene regulation ways and means, as well as the synthesis of a new mechanism of action of high activity, low toxicity side effects of retinoid compounds have important significance