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CERM 11 884是一种新的作用于心血管的药物,该药在pH 5.2时水溶性很小(2.2mg/ml),这给发展口服剂型带来困难。本文报道利用β-CD 来增加CERM11 884的溶解度,作者以CERM 11 884和-β-CD 按等克分子比例,分别采用简单混合、球磨研磨和固体包合三种办法制备了物理混合
CERM 11 884 is a new cardiovascular drug that has very low water solubility (2.2 mg / ml) at pH 5.2, making it difficult to develop oral dosage forms. This paper reports the use of β-CD to increase the solubility of CERM11 884. The authors prepared the physical mixture of CERM 11884 and -β-CD in equimolar proportions using simple mixing, ball milling and solid inclusion respectively