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目的探讨玉屏风颗粒联合双歧杆菌三联活菌散对迁延性腹泻患儿细胞免疫功能的影响及疗效。方法将76例迁延性腹泻患儿随机分为中西医组和西医组,中西医组予以玉屏风颗粒联合双歧杆菌三联活菌散治疗,西医组单纯予以双歧杆菌三联活菌散治疗。治疗8周后观察2组的临床疗效及细胞免疫功能的变化,随访6月观察复发情况。结果中西医组临床总有效率明显高于西医组(χ~2=5.21,P<0.05)。2组患儿治疗前血清CD_4~+,CD_8~+水平和CD_4~+/CD_8~+比值比较,差异均无统计意义(P>0.05);与同组治疗前比较,治疗后2组血清CD_4~+水平和CD_4~+/CD_8~+比值均显著上升(P<0.05或P<0.01),且中西医组上升幅度较西医组更为显著(P<0.05);2组患儿治疗前后CD_8~+水平无明显变化(P>0.05)。中西医组复发率明显低于西医组(χ~2=4.93,P<0.05)。结论玉屏风颗粒联合双歧杆菌三联活菌散治疗儿童迁延性腹泻疗效确切,能增强患儿的细胞免疫功能,并可降低复发率。
Objective To investigate the effect of Yupingfeng granule combined with Bifidobacterium triple viable powder on cellular immune function in children with persistent diarrhea. Methods 76 cases of persistent diarrhea in children were randomly divided into Western and Western medicine group, the Chinese and Western medicine group to Yupingfeng granules combined with Bifidobacterium triple viable powder treatment, Western medicine group was treated with Bifidobacterium triple live bacilli. After 8 weeks of treatment, the clinical curative effect and the changes of cellular immunity were observed. The recurrence was observed in June. Results The total effective rate of TCM and WM was significantly higher than that of WM (χ ~ 2 = 5.21, P <0.05). There was no significant difference in serum CD_4 ~ +, CD_8 ~ + levels and CD_4 ~ + / CD_8 ~ + ratio before treatment in both groups (P> 0.05). Compared with the same group before treatment, the serum levels of CD_4 ~ + And CD_4 ~ + / CD_8 ~ + ratio increased significantly (P <0.05 or P <0.01), and the increase rate of Chinese and Western medicine group was more significant than that of Western medicine group (P <0.05) ~ + Level no significant change (P> 0.05). The recurrence rate of Western medicine group was significantly lower than Western medicine group (χ ~ 2 = 4.93, P <0.05). Conclusion Yupingfeng granule combined with Bifidobacterium triple viable powder treatment of children with persistent diarrhea curative effect, can enhance children’s cellular immune function, and reduce the recurrence rate.