对于败血症引起的急性呼吸窘迫综合症(ARDS)的早期诊断尚无敏感的方法,有报告患者血清中血管紧张素转换酶(ACE)活性较低。为此,作者旨在观察给小鼠注入内毒素后,血清ACE的变化是否与败血症性ARDS病人相似,以提供一个研究用的动物模型。作者测定ACE活性的方法是,一部分血清与人造底物马尿酰-L-组氨酰-L-亮氨酸一起温育,37℃反 For the early diagnosis of acute respiratory distress syndrome (ARDS) caused by sepsis there is no sensitive way to report the lower serum ACE activity in patients. To do this, the authors sought to see if changes in serum ACE following endotoxin injection in mice were similar to those in septic ARDS to provide an animal model for the study. The authors tested ACE activity by incubating a portion of the serum with the human substrate, urokinase-L-histidyl-L-leucine, at 37 ° C