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目的探讨宫颈癌术前化疗在临床中的应用。方法对2012年1月至2012年6月开封市妇产医院收治的4例诊断宫颈癌Ⅱa～Ⅱb的患者,术前给予紫杉醇+卡铂的联合化疗方案2～3个疗程后行广泛性子宫切除术及盆腔淋巴结清扫术。结果 4例患者中有3例均在化疗后局部病灶缩小,临床分期降期,进行了广泛性子宫切除术、双侧附件切除术及盆腔淋巴结清扫术。其不良反应为轻微骨髓抑制和消化道反应,术中术后无严重并发症,术中出血300～400 ml。结论术前化疗近期疗效满意,尤其对于术前缩小局部肿块体积,降低临床分期有明显效果,使原来无法手术的患者有可能进行手术切除原发病灶。
Objective To investigate the clinical application of preoperative chemotherapy for cervical cancer. Methods From January 2012 to June 2012 in Kaifeng City Maternity Hospital admitted to 4 cases of cervical cancer Ⅱa ~ Ⅱb patients, preoperative paclitaxel + carboplatin combined chemotherapy regimen 2 to 3 courses of extensive uterus Resection and pelvic lymph node dissection. Results In 4 of the 4 patients, 3 cases were treated with extensive hysterectomy, bilateral accessory resection and pelvic lymphadenectomy after the local lesion was reduced and the clinical stage was reduced. The adverse reactions of mild myelosuppression and gastrointestinal reactions, postoperative no serious complications, intraoperative bleeding 300 ~ 400 ml. Conclusions The recent curative effect of preoperative chemotherapy is satisfactory, especially for reducing the volume of local lumps and reducing the clinical staging before surgery, which makes it possible to remove the primary lesion by surgery.