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目的探讨原发性双侧乳腺癌(Bilateral Pri mary Breast Cancer,BPBC)的预后及其相关影响因素。方法对新疆医科大学附属肿瘤医院1996年3月~2006年10月收治的54例BPBC患者的临床资料进行整理,并对患者进行随访观察,生存率采用Kaplan-Meier的方法计算,用Cox回归模型进行预后因素分析。结果 BPBC的5年累计生存率为57.9%,同时性原发性双侧乳腺癌(Synchronous BPBC,sBPBC)的生存率与异时性原发性双侧乳腺癌(Metachronous BPBC,mBPBC)的生存率相比差别无统计学意义(P>0.05)。单因素分析显示第一侧肿瘤分期、第二侧肿瘤分期、第二侧肿瘤激素受体情况对生存的作用有统计学意义。多因素分析表明第二侧肿瘤分期、第二侧肿瘤激素受体情况是影响患者生存的重要预后因素。结论双侧原发性乳腺癌的预后与两侧肿瘤均有关,在治疗过程中要兼顾二者情况,以提高患者的生存率。
Objective To investigate the prognosis and related factors of Bilateral Primal Breast Cancer (BPBC). Methods The clinical data of 54 patients with BPBC admitted to Cancer Hospital Affiliated to Xinjiang Medical University from March 1996 to October 2006 were collected. The patients were followed up and the survival rate was calculated by Kaplan-Meier method. Cox regression model Prognostic factors were analyzed. Results The 5-year cumulative survival rate of BPBC was 57.9%. The survival rate of synchronous primary BPBC (sBPBC) and survival rate of metastatic breast cancer patients with metachronous BPBC (mBPBC) The difference was not statistically significant (P> 0.05). Univariate analysis showed that the first side of the tumor staging, the second side of the tumor staging, the second side of the tumor hormone receptor status on the role of survival was statistically significant. Multivariate analysis showed that the second side of the tumor staging, the second side of the tumor hormone receptor status is an important prognostic factor in patients with survival. Conclusion The prognosis of bilateral primary breast cancer is related to both sides of the tumor. During the treatment, the prognosis of both cases should be considered in order to improve the survival rate of patients.