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作者回顾性检测了71例自1969～1983年在南加利福尼亚大学肝病科住院、HBsAg阳性、临床诊断为暴发性乙型肝炎(fulminant hepatitisB,FHB)病人血清中的δ标记物与HBV标记物,同时与118例HBsAg阳性的急性黄疸型乙型肝炎作比较。两组的流行病学背景相似。用放射免疫分析法(RIA)检测HBsAg、抗-HBcδ抗原、IgM抗-δ与IgG抗-δ;用固相阻断RIA法检测总体抗-δ;用RIA与免疫酶标法(Elisa)检测IgM抗-HBc。结果在71例FHB中,24例(33.8%)的血清有δ标记物。其中11例有IgM抗-δ而无IgG抗-δ,13例临床过程较长的在开始时都有高滴度的IgM抗-δ,以后其IgG抗-δ滴度升高。在有δ标记物的
The authors retrospectively reviewed the serum and serum levels of δ and HBV markers in 71 patients with HBsAg positive, clinically diagnosed fulminant hepatitis B (FHB) from 1969 to 1983 in the Department of Hepatology, University of Southern California, With 118 cases of HBsAg-positive acute jaundice hepatitis B for comparison. The epidemiological background of both groups is similar. HBsAg, anti-HBcδ antigen, IgM anti-δ and IgG anti-δ were detected by radioimmunoassay (RIA); total anti-δ was detected by solid-phase blocking RIA; detected by RIA and Elisa IgM anti-HBc. Results Of the 71 FHBs, 24 (33.8%) sera had delta markers. Eleven of them had IgM anti-delta and no IgG anti-delta. Thirteen patients with longer clinical course had a high titer of IgM anti-delta at the beginning, and their IgG anti-delta titers increased later. There are delta markers