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目的小剂量地塞米松联合氨溴索治疗早产儿支气管肺发育不良(bronchopulmonary dysplasia,BPD)的临床效果。方法选择126例BPD早产儿为研究对象,随机分为观察组(63例)和对照组(63例)。给予对照组地塞米松治疗,观察组应用地塞米松联合氨溴索治疗。比较两组吸氧时间、机械通气时间、出院时间及治疗疗效。结果观察组患儿吸氧时间、机械通气时间及出院时间均少于对照组,差异有统计学意义(P<0.05);观察组患儿治疗总有效率高于对照组,差异有统计学意义(P<0.05)。结论小剂量地塞米松联合氨溴索治疗早产儿BPD疗效突出,可有效缩短早产儿吸氧及机械通气时间,减少早产儿肺损伤程度,利于早产儿康复。
Objective To evaluate the clinical efficacy of low-dose dexamethasone combined with ambroxol in the treatment of bronchopulmonary dysplasia (BPD) in preterm infants. Methods 126 cases of premature infants with BPD were selected as study object and randomly divided into observation group (63 cases) and control group (63 cases). The control group was treated with dexamethasone and the observation group with dexamethasone and ambroxol. Oxygen intake time, mechanical ventilation time, discharge time and therapeutic effect were compared between the two groups. Results Oxygen inhalation time, mechanical ventilation time and discharge time in the observation group were less than those in the control group, the difference was statistically significant (P <0.05); the total effective rate in the observation group was higher than that in the control group, the difference was statistically significant (P <0.05). Conclusion Low-dose dexamethasone combined with ambroxol in the treatment of BPD in preterm infants has obvious curative effect, which can effectively shorten the duration of oxygen inhalation and mechanical ventilation in preterm infants, reduce the degree of lung injury in preterm infants and facilitate the recovery of premature infants.