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目的:探讨核受体孕烷X受体(PXR)在宫颈鳞癌组织的表达及与宫颈鳞癌发生的关系。方法:采用免疫组织化学及细胞免疫化学检测核受体PXR在41例宫颈癌组织及宫颈鳞癌细胞株SiHa中的表达。结果:PXR在宫颈鳞癌细胞株SiHa中有表达;正常宫颈组织有PXR表达,41例宫颈鳞癌组织中PXR的阳性率为59.5%,且宫颈癌组织中明显低表达。结论:PXR的表达水平与宫颈癌的发生有一定的相关性,可能成为今后判断宫颈癌预后有价值的标志物。
Objective: To investigate the expression of nuclear receptor pregnane X receptor (PXR) in cervical squamous cell carcinoma and its relationship with cervical squamous cell carcinoma. Methods: Immunohistochemistry and immunocytochemistry were used to detect the expression of nuclear receptor PXR in 41 cases of cervical cancer tissue and cervical squamous cell carcinoma cell line SiHa. Results: The expression of PXR in cervical squamous cell carcinoma cell line SiHa was detected. The expression of PXR was detected in normal cervical tissues. The positive rate of PXR in 41 cases of cervical squamous cell carcinoma was 59.5%, and was significantly lower in cervical cancer tissues. Conclusion: The expression of PXR has a certain correlation with the occurrence of cervical cancer, which may become a valuable marker for predicting the prognosis of cervical cancer in the future.