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为探讨幽门螺杆菌（ＨＰ）与胃癌前病变的关系，本文回顾性分析了４５１例因上腹部不适而在本院做胃镜的患者。共检查出ＨＰ阳性２４２例（５３．７％），ＨＰ感染时肠化生及胃粘膜萎缩的发生率分别为１４．９％（３６／２４２）及９．１％（２２／２４２），显著高于无ＨＰ感染的肠化生及萎缩发生率８．１％（１７／２０９）及３．３％（７／２０９）（Ｐ＜０．０５）。ＨＰ感染时发生肠化生及萎缩的平均年龄分别为４６．６±１４．５岁及３９．３±１３．７岁，显著小于无ＨＰ感染时的肠化生及萎缩年龄５６．２±９．２岁及５８．２±８．７岁（Ｐ＜０．０１）。本文结果提示早年感染ＨＰ可使肠化生及萎缩性胃炎发病率升高，故ＨＰ感染可能是胃癌的致病因素之一。
To investigate the relationship between Helicobacter pylori (HP) and precancerous lesions, we retrospectively analyzed 451 patients who underwent gastroscopy in our hospital because of upper abdominal discomfort. A total of 242 HP-positive cases (53.7%) were detected. The incidence of intestinal metaplasia and gastric mucosal atrophy during HP infection was 14.9% (36/242) and 9.1% (22/242), respectively. The incidence of intestinal metaplasia and atrophy higher than those without HP infection was 8.1% (17/209) and 3.3% (7/209) (P<0.05). The average age of intestinal metaplasia and atrophy during HP infection was 46.6±14.5 years and 39.3±13.7 years, respectively, which was significantly less than the age of intestinal metaplasia and atrophy without HP infection 56.2±9. 2 years old and 58.2±8.7 years old (P<0.01). The results of this study suggest that early infection with HP can increase the incidence of intestinal metaplasia and atrophic gastritis, so HP infection may be one of the pathogenic factors of gastric cancer.