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为探讨幽门螺杆菌(HP)与胃癌前病变的关系,本文回顾性分析了451例因上腹部不适而在本院做胃镜的患者。共检查出HP阳性242例(53.7%),HP感染时肠化生及胃粘膜萎缩的发生率分别为14.9%(36/242)及9.1%(22/242),显著高于无HP感染的肠化生及萎缩发生率8.1%(17/209)及3.3%(7/209)(P<0.05)。HP感染时发生肠化生及萎缩的平均年龄分别为46.6±14.5岁及39.3±13.7岁,显著小于无HP感染时的肠化生及萎缩年龄56.2±9.2岁及58.2±8.7岁(P<0.01)。本文结果提示早年感染HP可使肠化生及萎缩性胃炎发病率升高,故HP感染可能是胃癌的致病因素之一。
To investigate the relationship between Helicobacter pylori (HP) and precancerous lesions, we retrospectively analyzed 451 patients who underwent gastroscopy in our hospital because of upper abdominal discomfort. A total of 242 HP-positive cases (53.7%) were detected. The incidence of intestinal metaplasia and gastric mucosal atrophy during HP infection was 14.9% (36/242) and 9.1% (22/242), respectively. The incidence of intestinal metaplasia and atrophy higher than those without HP infection was 8.1% (17/209) and 3.3% (7/209) (P<0.05). The average age of intestinal metaplasia and atrophy during HP infection was 46.6±14.5 years and 39.3±13.7 years, respectively, which was significantly less than the age of intestinal metaplasia and atrophy without HP infection 56.2±9. 2 years old and 58.2±8.7 years old (P<0.01). The results of this study suggest that early infection with HP can increase the incidence of intestinal metaplasia and atrophic gastritis, so HP infection may be one of the pathogenic factors of gastric cancer.