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[目的]观察舒筋通络汤联合西药治疗糖尿病周围神经病变疗效。[方法]使用随机平行对照方法,将67例住院患者按随机数字表法分为两组。对照组32例控制空腹血糖<7.0mmol/L,或餐后2h血糖<10.0mmol/L,常规降血糖药物:二甲双胍,0.5g/次,2次/d,口服。格列吡嗪控释片,初始剂量为5mg/次,5~10g/d,口服。治疗组35例舒筋通络汤(黄芪、丹参各25g,葛根20g,桂枝18g,伸筋草15g,海风藤12g,川芎、全蝎、水蛭、蜈蚣各6g),1剂/d,水煎350mL,2次/d,口服;肢体灼热疼痛加赤芍、钩藤各15g;肢体冷痛加乳香、没药、附子各6g,艾叶12g;肢体麻木加鸡血藤25g。西药治疗同对照组。连续治疗15d为1疗程。观测临床症状、症状积分、不良反应。连续治疗2疗程,判定疗效。随访20d,观测复发率。[结果]治疗组显效21例,有效9例,无效5例,总有效率85.71%。对照组显效7例,有效11例,无效14例,总有效率56.25%。治疗组疗效优于对照组(P<0.01)。症状积分治疗组改善优于对照组(P<0.01)。[结论]舒筋通络汤联合西药治疗糖尿病周围神经病变效果显著,值得推广。
[Objective] To observe the curative effect of Shujin Tongluo Decoction combined with western medicine on diabetic peripheral neuropathy. [Methods] Randomized parallel method was used to divide 67 inpatients into two groups according to random number table. The control group of 32 patients controlled fasting blood glucose <7.0mmol / L, or 2h postprandial blood glucose <10.0mmol / L, conventional hypoglycemic drugs: metformin, 0.5g / time, 2 times / d, orally. Glipizide controlled release tablets, the initial dose of 5mg / time, 5 ~ 10g / d, orally. Treatment group, 35 cases of Shujin Tongluo Decoction (Astragalus, Salvia the 25g, Pueraria 20g, Guizhi 18g, Scrophulariaceae 15g, sea buckthorn 12g, Chuanxiong, Scorpio, leeches, centipede each 6g), 1 / d, water Fried 350mL, 2 times / d, oral; limb burning pain plus red peony root, Uncaria 15g; limb cold plus frankincense, myrrh, aconite each 6g, Ai leaf 12g; numbness plus Millettia 25g. Western medicine treatment with the control group. Continuous treatment 15d for a course of treatment. Observed clinical symptoms, symptom scores, adverse reactions. Continuous treatment of 2 courses to determine the efficacy. Followed up for 20 days, observed the recurrence rate. [Result] In the treatment group, 21 cases were markedly effective, 9 cases effective, 5 cases ineffective, and the total effective rate was 85.71%. The control group markedly effective in 7 cases, effective in 11 cases, invalid in 14 cases, the total effective rate was 56.25%. The treatment group than the control group (P <0.01). The symptom score improved better than the control group (P <0.01). [Conclusion] Shujin Tongluo Decoction combined with western medicine has significant effect on diabetic peripheral neuropathy and is worth popularizing.