采用兔顶骨矢状缝扩张模型，用放射免疫法测定骨缝扩张后内源性ＰＧＥ２含量的变化规律，结果表明：兔矢状缝受力后，ＰＧＥ２含量在早期升高，表明骨吸收活动在受力后初期即发生，但骨缝对不同大小的力反应有所不同，０．１０ｋｇ力引起组织持续的改建活动，ＰＧＥ２含量一直保持较高水平；０．２０ｋｇ力可能引起组织破坏，骨改建活动不如０．１０ｋｇ力组明显。该研究结果提示：在临床矫形治疗中应注意合理施力 Using the rabbit parietal sagittal suture dilatation model, the changes of endogenous PGE2 content after suture expansion were measured by radioimmunoassay. The results showed that the content of PGE2 increased in the early stage after the sagittal suture was stressed, indicating that the bone resorption activity was in the Force early after the occurrence, but the suture different force response to different sizes, 0.10kg force caused by continuous tissue remodeling activities, PGE2 content has remained high; 0.20kg force may cause tissue damage, bone remodeling Activities than 0.10kg force group obvious. The results suggest that: in clinical orthopedic treatment should pay attention to reasonable force